On the levels of enzymatic substrate specificity: implications for the early evolution of metabolic pathways.

The most frequently invoked explanation for the origin of metabolic pathways is the retrograde evolution hypothesis. In contrast, according to the so-called "patchwork" theory, metabolism evolved by the recruitment of relatively inefficient small enzymes of broad specificity that could react with a wide range of chemically related substrates. In this paper it is argued that both sequence comparisons and experimental results on enzyme substrate specificity support the patchwork assembly theory. The available evidence supports previous suggestions that gene duplication events followed by a gradual neoDarwinian accumulation of mutations and other minute genetic changes lead to the narrowing and modification of enzyme function in at least some primordial metabolic pathways.     

The chemical profiles of polar ice on Earth and Mars: What we read from the first; what we could read from the second

An analogy is drawn between the current knowledge on terrestrial snow and ice-cap chemistry and the possible composition of snowfall and ice caps of Mars. Terrestrial snowfall reflects the composition of the Earth's atmosphere. Snow cover further interacts with the atmosphere and is the recipient of aerosol and particulate fall-out. The snow is transformed to firn and ice and the chemical signatures become locked into the perennial ice sheets. The chemical profiles of ice thus constitute environmental records of the Earth's past. By considering the present knowledge on the hydrologie cycle of Mars and the chemistry of the atmosphere, a simple analogous model for the chemical profile of the North polar ice cap is proposed. Three major constituents of the ice are discussed: water ice, dust, and occluded air bubbles. The seasonal fluctuations and interannual variability of these components are examined as possible chemical signatures for the dating of ice, elucidating hydrologie processes, and recording long-term climatic change. The model of the north polar cap in summer consists of water-ice fine-dust layers (30–200 m thick) sandwiched between annual dust layers of variable size distribution and thickness (< 1m– > 66 m). The water ice is subjected to metamorphism and grain growth. The interpretation of the physico-chemical profile could lead to increased knowledge on the recent climatic past (1,000–2,000 years), hydrologic reservoirs, and seasonal cycles in the atmospheric dynamics of the planet.     

Cosmic-ray intensity variations in the 3-dimensional heliosphere

The study of cosmic-ray intensity variations have been carried out with data registered by ground-based and balloon-borne equipment for the past 50 years or more. The International Geophysical Year (IGY) from July 1957 to December 1958 gave an impetus to global collaborations. A world-wide network of concerted measurements became available with the advent of the space age.In situ measurements by satellite-borne detectors led to deep-space exploration. The spacecraft Pioneers and Voyagers, during the past 15 years, traversing farther out into the heliosphere at increasing radial distances from the sun have changed the study of time variations into one of time and spatial variations.Furthermore, with the Voyager 1, proceeding asymptotically towards heliolatitudes of 35° north since its encounter with Saturn and the anticipated direction of Voyager 2 after its encounter with Neptune in late-1989 towards 48° south heliolatitude, is converting the study into a truly three-dimensional exploration of the heliosphere. Thus, the investigation of galactic cosmic-ray intensity variations fromin situ measurements deep in the heliosphere in distance, latitude, and over solar cycles is indeed a remarkable achievement.The various cosmic-ray intensity variations over different time-scales, the modulation of the intensity by the evolving solar activity and the role of the electromagnetic state of the interplanetary medium (otherwise called heliosphere) can now be investigated as never before; these studies contribute immensely to our knowledge of the solar neighbourhood. This article essentially deals with the studies of time and spatial variations of cosmic-ray intensity that have been conducted especially over the past two decades.     

Pitch-angle diffusion and the origin of temporal and spatial structures in morningside aurorae

Morningside aurorae at latitudes below about 70° display complex spatial and temporal structures unlike anything seen in the evening or midnight sectors. The morningside structures are believed to be formed by the precipitation of trapped electrons injected in auroral substorms; no significant role has yet been identified in the morningside auroral regions for the large-scale parallel electric fields that dominate the evening side. How those spatial and temporal structures originate has been the subject of much speculation; most theoretical mechanisms focus on the wave-particle interactions that drive pitch-angle diffusion. The principal evidence pertaining to the role of pitch-angle diffusion in the auroral regions is reviewed here. The observational evidence concerns mainly auroral emissions in the atmosphere, energetic particles observed from rockets and satellites, VLF waves at high altitudes, magnetospheric cold plasma, and magnetic pulsations detected on the ground. With the aid of such evidence, plus observations and theories related to the outer permanently trapped radiation belts, several theoretical models for the modulation of VLF wave growth in the equatorial regions have been pieced together. Those models, and the observational data supporting them, are examined to see how well they fit the observational picture and to see where they might lead in future research. The models fall into two categories: those in which the modulations are externally imposed and those in which the modulations are self-excited. For the temporal variations the self-excited mechanisms are now favored. The leading candidate involves a nonlinear relaxation oscillator; the nonlinearity may have important consequences. There are several contenders in both categories for the origin of the spatial structures, none of which agrees fully with inferences from the observations. All the theories involve critical parameters that have not yet been precisely fixed. The critical research needs are listed and discussed.     

Radar Cross Section of Ships

A laboratory method to determine the magnitude and position of radar reflection sources on complex targets is described. In addition the method provides a way to measure the modification of the radar cross section (RCS) due to multipath. The method has application in modeling RCS for radar and electronic countermeasure (ECM) system performance analysis and in the study of the extent to which the signature of the target could be altered. The equipment described, termed MACROSCOPE, was developed for RCS studies by the U.S. Army and is described in limited distribution bution literature. The application to marine targets is new with this paper, as is the technique of measuring the RCS of parts of the target and analytically combining them to represent the whole. An illustration of the need for this type of laboratory equipment was illustrated by the extensive search for full scale data which could be compared to scale model data to validate the technique.     

Initial ISEE magnetometer results: magnetopause observations

The magnetic field profiles across the magnetopause obtained by the ISEE-1 and -2 spacecraft separated by only a few hundred kilometers are examined for four passes. During one of these passes the magnetosheath field was northward, during one it was slightly southward, and in two it was strongly southward. The velocity of the magnetopause is found to be highly irregular ranging from 4 to over 40 km s^-1 and varying in less time than it takes for a spacecraft to cross the boundary. Thicknesses ranged from 500 to over 1000 km.Clear evidence for reconnection is found in the data when the magnetosheath field is southward. However, this evidence is not in the form of classic rotational discontinuity signatures. Rather, it is in the form of flux transfer events, in which reconnection starts and stops in a matter of minutes or less, resulting in the ripping off of flux tubes from the magnetosphere. Evidence for flux transfer events can be found both in the magnetosheath and the outer magnetosphere due to their alteration of the boundary normal. In particular, their presence at the time of magnetopause crossings invalidates the usual 2-dimensional analysis of magnetopause structure. Not only are these flux transfer events probably the dominant means of reconnection on the magnetopause, but they may also serve as an important source of magnetopause oscillations, and hence of pulsations in the outer magnetosphere. On two days the flux transfer rate was estimated to be of the order of 2 × 10¹² Maxwells per second by the flux transfer events detected at ISEE. Events not detectable at ISEE and continued reconnection after passage of an FTE past ISEE could have resulted in an even greater reconnection rate at these times.     

Study of shaping strategies for blisk vane channels by a cup tool

This paper deals with roughing milling of vane channels for axial blisks by a cup tool. The effect of the shaping strategy on waviness of the surfaces being machined and allowance for subsequent operations is determined.     

Theory of physical libration of the Moon with the liquid core: Forced librations

For a two-layer model of the Moon that consists of a solid nonspherical mantle and an ellipsoidal homogeneous liquid core, a theory of forced librations under the effect of gravitational Earth’s moments has been developed. The motion of the Moon over its orbit has been described by the high-accuracy theory of DE/LE-4 orbital motion. Tables have been constructed that present forced librations of the Moon caused by the second harmonic of its force function, in the neighborhood of its motion according to the generalized Cassini laws. Disturbances of the first-order with respect to dynamic compressions of the Moon and its core are obtained in analytical form for Andoyer variables and Poincare variables and for the projection of the angular velocity vector of Moon’s mantle rotation and the Poincare coordinate system (relative to which core’s liquid accomplishes simple motion) on its major central axes of inertia, as well as for the classical variables in the Moon libration theory, etc. Constructed tables of the forced librations theory give the amplitudes and periods of librations and combinations of arguments of the orbital motion theory that correspond to libration parameters. The interpretation of basic variations has been given and a comparison with the previous theories has been carried out, in particular with the modern empirical theory constructed based on the laser observation data.     

Study of the variability of blazars gamma-ray emission

The γ-ray emission of blazar jets shows a pronounced variability and this feature provides limits to the size and to the speed of the emitting region. We study the γ-ray variability of bright blazars using data from the first 18 months of activity of the Large Area Telescope on the Fermi Gamma-Ray Space Telescope. From the daily light-curves of the blazars characterized by a remarkable activity, we firstly determine the minimum variability time-scale, giving an upper limit for the size of the emitting region of the sources, assumed to be spheroidal blobs in relativistic motion. These regions must be smaller than ∼10⁻³ parsec. Another interesting time-scale is the duration of the outbursts. We conclude that they cannot correspond to radiation produced by a single blob moving relativistically along the jet, but they are either the signature of emission from a standing shock extracting energy from a modulated jet, or the superposition of a number of flares occurring on a shorter time-scale. We also derive lower limits on the bulk Lorentz factor needed to make the emitting region transparent for gamma-rays interacting through photon–photon collisions.